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Articolul urmator |
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Ultima descărcare din IBN: 2024-03-17 18:55 |
SM ISO690:2012 CERNOVA, Natalia, DIUG, Eugen, CIOBANU, Nicolae, GURANDA, Diana, CIOBANU, Cristina, SOLONARI, Rodica. Formularea medicamentelor cu eliberare vectorizată în colon. In: Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”, 21-23 octombrie 2020, Chişinău. Chişinău: USMF, 2020, p. 653. |
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Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” 2020 | |||||||
Congresul "Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”" Chişinău, Moldova, 21-23 octombrie 2020 | |||||||
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Pag. 653-653 | |||||||
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Background. Vectorized drugs release into the colon is required for the local treatment of various diseases. The purpose of a vectorized delivery system consists in protection of the active substance from the action of gastric and intestinal juice and to release the drug to the site of action. Objective of the study. Study of the literature in order to highlight the types of systems and excipients susceptible to colon delivery. Material and Methods. The main sources of information on the results of research regarding the specific transport systems in the colon and the excipients used in their formulation were selected. Results. Due to its high water absorption capacity, the content of the colon are considerably viscous, the more than 400 species of bacteria cause various reactions such as azoreduction and enzymatic cleavage, and they are responsible for the metabolism of many drugs. The transport of drugs in the colon can be done using different systems, processes and formulation excipients: pH-dependent polymers (6.6-7.0); delayed release systems (after 5-6 hours); microbiologically biodegradable polymers; enzymatically hydrolyzable drug precursors; azopolymers; polysaccharide (chitosan); osmotic systems with controlled release (OROS-CT, push pull). Conclusion. The formulation of therapeutic systems with the use of new excipients, allows the localization of the action in the colon, thus contributing to the optimization of pharmacotherapy in this segment of gastrointestinal trac |
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Cuvinte-cheie colon, treatment, vector release, formulation, colon, Tratament, eliberare vectorizată, formulare |
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