Articolul precedent |
Articolul urmator |
365 2 |
Ultima descărcare din IBN: 2023-12-24 14:17 |
SM ISO690:2012 VOLOC, Alexandru. Particularitățile clinice, paraclinice și evolutive ale formelor grave de paludism la copii. In: Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”, 21-23 octombrie 2020, Chişinău. Chişinău: USMF, 2020, p. 561. |
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Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” 2020 | ||||||
Congresul "Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”" Chişinău, Moldova, 21-23 octombrie 2020 | ||||||
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Pag. 561-561 | ||||||
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Background. Severe forms of malaria are a subject of current public health events in intertropical Africa, representing around 25% of all hospital admissions to pediatric wards, being responsible for a mortality between 3 and 20% and a high morbidity between 31% and 71% in the Republic of Gabon. Objective of the study. Studying the clinical, laboratory, therapeutic and evolutive features of severe forms of malaria in children of different age. Material and Method. A retrospective descriptive unicentric study with a review of 104 medical records of children ages 0-15 y – 44 girls (F) and 6- boys (M), hospitalized in UMCHC emergency ward. Examined parameters: age, sex, blood counts, thick blood drop smear for malaria (TD), parasitemia, parasite density (PD), rapid diagnostic test (RDT), biochemical tests and clinical picture. Results. Severe cerebral malaria - 89(85.6%) cases, incl. 11(10.6%) in coma (Blantyre 2/5). Neuromalaria - in children with the comatose state evolving in <30 min. and/or ≥ 2 generalized seizures in 24 h and/or in convulsive status. PD - 4.41%±1.78(F), 11.76%±5.23(M) p<0.001. In 15(14.4%) cases severe parasitic form (DP>5%). P.falciparum in 104(100%), anemia – 103(99.03%), tonic-clonic generalized seizures 48(46.1%) cases. Splenomegaly I-II (Hackett) – 77(74.0%), with positive predictive value for disease evolution (p<0.001). Hepatomegaly in 2(1.8%) cases associated with negative evolution (p<0.05). Parasitemia 68531±12600 trophozoites/μl (F), 154424±131611 trophozoites/μl (M) (p<0.05). Conclusion. Cerebral and parasitic malaria - the most common forms caused by P.falciparum. Splenomegaly is a predictor of a favorable evolution (p<0.001). Hepatomegaly is a predictor of unfavorable evolution (p<0.05). Isolated increased parasitemia- possible sign of delayed antimalarial treatment initiation. |
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Cuvinte-cheie malaria, neuromalaria, children, paludism, neuropaludism, copii |
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