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Articolul urmator |
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SM ISO690:2012 EREMCIUC, Rodica, REVENCO, Ninel. Particularitățile creșterii la copiii de vârstă prepubertară cu artrită juvenilă idiopatică. In: Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”, 21-23 octombrie 2020, Chişinău. Chişinău: USMF, 2020, p. 531. |
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Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” 2020 | ||||||
Congresul "Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”" Chişinău, Moldova, 21-23 octombrie 2020 | ||||||
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Pag. 531-531 | ||||||
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Background. The effect of inflammation causes delayed growth in children, ranging from mild to severe short stature. There are insufficient data to elucidate peripheral hormonal resistance in the process of delayed growth in children with juvenile idiopathic arthritis [JIA]. Objective of the study. To evaluate growth velocity in children with different onset subtypes of JIA and to correlate clinical data with immunological hormone value and pituitary autoimmune activity. Material and Method. The study included analyzing the data of 45 patients younger than 11 y.o. with the diagnosis confirmed of JIA, at baseline and follow-up at 6, 12 and 18 months. Auxological analysis and growth velocity were expressed by Z-score, according to the WHO 2007 statistical database. The hormonal profile included serum determination of central and peripheral hormones, and pituitary autoantibodies. Results. Analysis of demographic data revealed: mean age 7.28 ± 0.83 years; the mean age at onset was 5.2 ± 0.47 years; sex ratio F: M = 1.63: 1. The most common category of AJI was sero-negative polyarthritis (39%). At enrollment, the Z score for the height was −0.54 DS (CI: −4.71, +1.17). 18% subjects were established with delayed growth (score Z <−2 DS), and 14% with low values of insulin growth factor [CI: 37.4; 79.2]. The Z score for height at 6 months decreased by -0.47 and -0.63 at 12 months. In the study, no disorders involving protein. Conclusion. JIA with systemic onset and the younger age at onset determine the most severe growth impairment. Pituitary autoimmune process was not detected in children with JIA complicated by delayed growth. |
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Cuvinte-cheie growth, antihypophisary antibodies, Juvenile idiopathic arthritis, creştere, anticorpi antihipofizari, artrită juvenilă idiopatică |
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