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SM ISO690:2012 PROCOPCIUC, Vitalie, MIHALUŢA, Viorica, IGNATOV, Olga. Eficiența transplantului de membrană amniotică în managementul deficienței de celule stem limbale. In: Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”, 21-23 octombrie 2020, Chişinău. Chişinău: USMF, 2020, p. 490. |
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Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” 2020 | |||||
Congresul "Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”" Chişinău, Moldova, 21-23 octombrie 2020 | |||||
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Background. Due to its mechanical and biological properties, the amniotic membrane (AM) has a wide range of indications in the treatment of ocular surface diseases. Applied alone or in combination with other types of limbal transplantation, AM provides support for transplanted limbal tissues and stem cells. Objective of the study. To analyze the current data on applications of AM in the surgical management of limbal stem cell deficiency (LSCD) and to summarize the results of various surgical approaches. Material and Methods. A systematic search was performed on PubMed for papers published until February 2020, using combinations of the following search terms: "amniotic membrane", "limbal stem cell deficiency", "limbal transplantation", "conjunctival limbal auto-/allograft", ” keratolimbal allograft”. The data on AM preparation, as well as surgical techniques and clinical results was collected and analyzed. Results. The surgical approach for treating LSCD varies depending on the severity of the pathology. Isolated AM transplantation appears to have a limited effect on the limbal stem cells in the long term. Combined with diverse types of limbal stem cell transplantation, the AM provides biological and mechanical support, as well as protection of newly transplanted tissues. Associated with simple limbal epithelial transplantation, AM has shown excellent results in the surgical management of LSCD. Complete epithelialization of the cornea occurred on average after 4 weeks, and an avascular corneal surface at 6 months after the intervention was reported in the vast majority of cases. Conclusion. Preliminary results of the application of AM in limbal transplantation show quite satisfactory data, but the lack of high-level studies, such as randomized controlled clinical trials, make it difficult to assess the comparative efficacy of AM transplantation in the surgical management of LSCD. |
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Cuvinte-cheie amniotic membrane, limbal stem cell deficiency, limbal graft, membrana amniotică, deficiență ce celule stem limbale, grefă limbală |
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