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SM ISO690:2012 IURCIUC, Vladislav, HOTINEANU, Adrian, TARAN, Natalia, BERLIBA, Elina, TOACĂ, Inesa I.. Evaluarea scorului meld și a scorurilor meld derivate în predicția mortalității pe termen scurt după transplant hepatic . In: Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”, 21-23 octombrie 2020, Chişinău. Chişinău: USMF, 2020, p. 419. |
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Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” 2020 | ||||||
Congresul "Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”" Chişinău, Moldova, 21-23 octombrie 2020 | ||||||
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Pag. 419-419 | ||||||
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Background. MELD score and derived MELD scores estimate survival at 3 months in patients with decompensated liver cirrhosis on the waiting list for liver transplantation. It is unclear whether these scores would be important in the prognosis of short-term mortality after liver transplantation. Objective of the study. Assessment of the ability of MELD score and derived MELD scores to predict short-term post-transplant mortality in patients who received liver transplantation in the Republic of Moldova. Material and Methods. A retrospective cohort study was performed, analyzing data from 53 patients who received a liver transplant in 2013-2020. The MELD score and its modified variants (MELD-Na, iMELD, uMELD, UKELD) were used to test the predictive power of short-term posttransplant mortality, compared by ROC analysis and diagnostic accuracy. Results. The final group consisted of 53 patients with a mean age of 47.4 years. The most common indication for transplantation was cirrhosis due to HDV (49%). The mortality rate at 3 months after transplantation was 17%. The MELD score obtained an area under the ROC curve - 0.68, and from the derived MELD scores the greatest areas were reported at iMELD - 0.77, followed by UKELD - 0.72. MELD-Na stood out with the highest diagnostic accuracy - 79.25% and specificity - 81.4%. The highest sensitivity was reported at iMELD - 88.9%, but also the lowest specificity - 52.3%. Conclusion. The MELD score did not prove to be a useful tool in predicting short-term post-transplant mortality, and of the derived MELD scores the most effective in this regard was MELD-Na. |
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Cuvinte-cheie liver transplantation, prognostic score, mortality, MELD-Na, transplant hepatic, scor prognostic, mortalitate, MELD-Na |
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