Articolul precedent |
Articolul urmator |
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Ultima descărcare din IBN: 2024-03-04 11:02 |
SM ISO690:2012 MUNTEANU, Cristina, AFTENE, Daniela. Encefalita cu anticorpi anti-receptori de n-metil-d-aspartat – provocări în diagnostic și management (caz clinic). In: Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”, 21-23 octombrie 2020, Chişinău. Chişinău: USMF, 2020, p. 326. |
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Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” 2020 | ||||||
Congresul "Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”" Chişinău, Moldova, 21-23 octombrie 2020 | ||||||
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Pag. 326-326 | ||||||
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Background. Anti-N-methyl-D-aspartate receptor encephalitis is an autoimmune encephalitis, although discovered since 2007 it remains unrecognized. Patients develop a polymorphism of symptoms, with an unnoticed prodromal phase, but with psychiatric or neurological manifestations occurence, requires treatment. Objective of the study. Assessment of challenges that intervene in the diagnosis and management of anti-N-methyl-D-aspartate receptor encephalitis based on a clinical case presentation and literature review. Material and Methods. Patient, 27 years old, hospitalized after 2 focal epileptic seizures, with impaired awareness and evolution to bilateral tonic-clonic, primarily detected, without a history of neurological, psychiatric pathology or seizures. From anamnesis, 3 days before the hospitalization, the patient was discharged from the gynecology department, where she underwent laparoscopic left ovarian cystectomy. Results. Hospitalized she developed psychiatric symptoms, even catatonia, without neurological impairments or meningeal signs. Paraclinical, imagistic without abnormalities, histological - mature ovarian cystic teratoma. Subsequently, as the psychiatric symptoms progressed, she was referred to a psychiatric hospital, preventively collecting serum anti-NMDA-R antibodies. After obtaining the positive result, she was readmitted, reevaluated by electroencephalography, excluded the delta brush pattern or non-convulsive seizures, brain and pelvic MRI without changes. Initiated specific treatment - plasmapheresis, with improvement of the psychoneurological condition, then oral corticosteroids. Conclusion. Anti-NMDA-R encephalitis is a severe disease, requiring greater emphasis to clinical and paraclinical manifestations, antibodies determination, to prevent misdiagnosis. The case illustrates the importance of suspecting autoimmune encephalitis, although the results of antibody testing are delayed. |
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Cuvinte-cheie anti-NMDA-R encephalite, autoimmune encephalitis, ovarian teratoma, anti-NMDA-R encefalită, encefalite autoimune, teratom ovarian |
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