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Articolul urmator |
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Ultima descărcare din IBN: 2022-06-24 09:08 |
SM ISO690:2012 BRINZA, Gabriela. Efectele estrogenilor asupra plasticității creierului. In: Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”, 21-23 octombrie 2020, Chişinău. Chişinău: USMF, 2020, p. 77. |
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Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” 2020 | ||||||
Congresul "Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”" Chişinău, Moldova, 21-23 octombrie 2020 | ||||||
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Pag. 77-77 | ||||||
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Rezumat | ||||||
Background. Estrogens have efects not only on gonads but also on the hippocampus and the prefrontal cortex area. The fluctuations of estrogen levels can directly influence cognitive functions, an important point in physiological or surgical menopause management. Objective of the study. To study the importance of estrogens in neuroprotection and the effectiveness of hormonal therapy depending on the age, type (natural/ induced) and stage (early/ late) of the menopause. Material and Methods. This is the synthesis of 20 medical research articles published in the period 2014-2019, found with the research motors PubMed, NCBI and Sciencedirect. Results. Clinical studies have proved that estrogens mediated effects as a result of interaction with the receptors ERα, ERβ and GPER1 from the neurons of the hippocampus and prefrontal cortex. Estrogens mediate the dendritic density growth thus helping the formation of new synapses, stimulating the glycolytic over ketogenic metabolism, and maintaining Ca⁺ homeostasis. These effects are important for the optimal functioning of the memory and for the reduction of neurodegenerative processes. The lower levels of circulating estrogens during menopause can cause memory alterations, neural hypometabolism and for in the long term, the risk of developing dementia. Conclusion. Hormone replacement therapy for the promotion of neuroprotection shows eficacy depending on the time of administration and reported to the natural or surgical menopause onset. |
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Cuvinte-cheie estrogen, menopause, hormone therapy, dementia, estrogen, menopauză, terapie hormonală, demenţă |
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