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SM ISO690:2012 VASILACHE, Eugenia, CARACAŞ, Anastasia. Hepatotoxicitatea vitaminelor liposolubile A şi E. In: Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”, 21-23 octombrie 2020, Chişinău. Chişinău: USMF, 2020, p. 72. |
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Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” 2020 | |||||
Congresul "Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”" Chişinău, Moldova, 21-23 octombrie 2020 | |||||
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Pag. 72-72 | |||||
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Rezumat | |||||
Background. The share of drug-induced liver diseases, caused by fat-soluble vitamins used uncontrollably, varies from 2 to 20 percent. Vitamins A and E, along with the beneficial effects, can exert toxic action on the liver manifested by hepatitis, non-cirrhotic portal hypertension. Objective of the study. To analyze reports of hepatotoxicity of fat-soluble vitamins A and E and to characterize the clinical and paraclinical aspects of liver damage when using vitamin preparations with elucidation of the mechanisms underlying liver toxicity. Material and Methods. A clinical case of administration of AEVIT 15 capsules / day for 2 years was analyzed (doses of vitamin E 1500 IU / day and vitamin A 1500000 IU / day). Results. The patient was hospitalized with the accusations: embarrassment in the right hypochondrium and epigastrium, weakness, dry skin, hair loss, abdominal distension, peripheral edema. Examination found: sclera jaundice, hepatomegaly ( + 1.5 cm) and splenomegaly ( + 3 cm ) , moderate increase in aspartate aminotransferase and alkaline phosphatase , hypoalbuminemia, and liver elastography - signs of cirrhosis. Liver biopsy: focal lobular hepatitis and enlarged, lipid-laden, stellate cells with varying degrees of sinusoidal fibrosis. Abdominal ultrasonography: signs of extrahepatic portal hypertension and signs of nonalcoholic steatosis. Conclusion. Portal hypertension in hypervitaminosis A and E is caused by obstruction of the perisinusoidal spaces Disse as a result of hyperplasia and hypertrophy of stellate cells stimulated by lipid vacuoles in the cytoplasm with collagen production and the development of perisinusoidal fibrosis |
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Cuvinte-cheie Vitamin A, vitamin E, drug hepatitis, hypervitaminosis, vitamina A, vitamina E, hepatită medicamentoasă, hipervitaminoză |
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