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SM ISO690:2012 BALUȚEL, Ana. Mecanismele celularo-moleculare în dezvoltarea peritonitei. In: Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”, 21-23 octombrie 2020, Chişinău. Chişinău: USMF, 2020, p. 62. |
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Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” 2020 | ||||||
Congresul "Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”" Chişinău, Moldova, 21-23 octombrie 2020 | ||||||
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Pag. 62-62 | ||||||
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Rezumat | ||||||
Background. Peritonitis is an inflammatory process involving cells, vascular changes, synthesis of proinflammatory (IL-6,TNF-α) and anti-inflammatory (IL-10,IL-27) mediators which maintain inflammation. The mechanisms that determine the evolution and prognosis of peritonitis are not fully elucidated. Objective of the study. Studying the evolution of cellular-molecular changes in the peritoneum and blood in correlation with the pathogen. Identifying the new pathogenetic links for the optimal methods of diagnosis and treatment of peritoneal sepsis. Material and Methods. The current references from the international scientific literature were examined, implicitly the databases of the electronic libraries PubMed, GeneCards and Annals of Translational Medicine. Results. The cytokine cascade triggered in peritonitis correlates with the pathogen: anaerobic agent increasing plasma in TNFα, enterococcal agent increasing peritoneal in INF-γ, polymicrobial agents increasing peritoneal in IL10, increasing in IL-27 specific for zimosan infection. ADM (adrenomedullin) precursor, MR-proADM increases significantly depending on the severity of sepsis: in healthy patients -0.4 nmol/L, in patients with SIRS - 1.1 nmol/L, in septic patients 1.8 nmol/L, in severely septic patients - 2.8 nmol/L, in patients with septic shock - 4.5 nmol/L and in those who need norepinephrine- 5.5 nmol/L. Conclusion. The evolution of peritonitis depends on the immune system of the patient, the pathogen, and the cellularmolecular mechanism. Quantitative measurement of cells and cytokines can be used as a tool for early diagnosis of the severity of pathology. |
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Cuvinte-cheie cytokines, interleukins, biomarkers, peritonitis, sepsis, citokine, interleukine, biomarker, peritonită, sepsis |
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