Articolul precedent |
Articolul urmator |
220 1 |
Ultima descărcare din IBN: 2021-05-13 10:03 |
SM ISO690:2012 TOMA, Alina, VIŞNEVSCHI, Anatolie. Provocări în diagnosticul de laborator al infecției cu COVID-19: negativ, dar pozitiv. In: Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”, 21-23 octombrie 2020, Chişinău. Chişinău: USMF, 2020, p. 57. |
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Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” 2020 | ||||||
Congresul "Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”" Chişinău, Moldova, 21-23 octombrie 2020 | ||||||
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Pag. 57-57 | ||||||
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Rezumat | ||||||
Background. As of December 2019, in just 5 months, the new disease (COVID-19) pandemic has expanded to 216 countries and affected more than four million people. This has led to numerous challenges in the laboratory diagnosis of COVID infection – 19, one of which is the occurrence of false negative cases. Objective of the study. Analysis of the possible causes of false negative results in the diagnosis of patients with COVID-19 and how such situations should be corrected. Material and Methods. A systematic review of literature has been carried out using Medline databases, Pub Med, to identify the relevant items, referring to ‘COVID-19’, ‘Laboratory diagnosis’, ‘false negative’. Results. The current gold standard for the etiological diagnosis of SARS-CoV-2 infection is (real-time) reverse transcription polymerase chain reaction (RT-PCR). The fact that RT-PCR testing may be initially negative is not surprising considering the probable kinetics of SARS-CoV-2 infection. Tests performed outside the diagnostic window, insufficient viral RNA, the sensitivity of the kit-PCR, thermal inactivation, are situations which may lead to false negative results. To control these possible errors it is important to use other methods that tests based on IgM/IgG antibodies, or a relevant role, pertain to pulmonary computed tomography. Conclusion. A positive result confirms virus detection, but a negative result does not always mean the absence of infection, so a single method is not sufficient for final diagnosis, but should be used taking into account epidemiological, clinical, paraclinical characteristics. |
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Cuvinte-cheie COVID-19, laboratory diagnosis, false negative, COVID-19, diagnostic de laborator, fals negativ |
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