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Articolul urmator |
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Ultima descărcare din IBN: 2023-05-11 17:09 |
SM ISO690:2012 DUMITRAS, Mariana. Rolul micro-RNA în fibrinoliză. In: Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”, 21-23 octombrie 2020, Chişinău. Chişinău: USMF, 2020, p. 41. |
EXPORT metadate: Google Scholar Crossref CERIF DataCite Dublin Core |
Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” 2020 | |||||
Congresul "Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”" Chişinău, Moldova, 21-23 octombrie 2020 | |||||
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Pag. 41-41 | |||||
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Rezumat | |||||
Background. Micro-RNAs (miRNAs) were defined as small endogenous non-coding RNAs consisting of 18-24 nucleotides, responsible for the gene expression and involved in many cellular processes. The exact role of miRNA in the coagulation-fibrinolysis cascade was the subject of several studies. Objective of the study. To study the literature data regarding the role of miRNA in the processes of fibrinolysis for identifying the possible diagnostic and therapeutic strategies. Material and Methods. There were analyzed: Wiley Online library, Crossref, Google Scholar databases, using the combination of the terms “miRNA in fibrinolysis”, “regulation of plasminogen activator inhibitor-1” in the articles published between years 2012-2020. Results. The expression of the enzyme plasminogen activator inhibitor-1 (PAI-1), the main modulator of thrombosis, fibrinolysis, inflammation, angiogenesis and atherogenesis, encoded by SERPINE-1 locus, was inhibited by miR-421 and miR-30c in human endothelial cells by exerting direct inhibition in the 3′UTR of SERPINE-1 mRNA, and stimulated by miR-301. There was observed serum elevation of miR-320a, miR-320b, miR-424-5p, miR-532 in deep vein thrombosis. The resolution of experimental venous thrombosis was due to the overexpression of miR-150, miR-126, miR-21 and inhibition of miR-483-3p. Conclusion. A number of miRNAs were suggested both as potential biomarkers for the diagnosis of thrombotic disorders, and as a treatment perspective for venous thrombosis. |
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Cuvinte-cheie fibrinolysis, miRNA, fibrinoliză, miRNA |
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