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Articolul urmator |
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Ultima descărcare din IBN: 2023-01-13 14:19 |
SM ISO690:2012 TOMA, Alina, VIŞNEVSCHI, Anatolie. Rolul enzimei de conversie a angiotensinei 2 în patogenia infecției cu COVID-19. In: Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”, 21-23 octombrie 2020, Chişinău. Chişinău: USMF, 2020, p. 35. |
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Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” 2020 | ||||||
Congresul "Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”" Chişinău, Moldova, 21-23 octombrie 2020 | ||||||
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Background. The angiotensin-converting enzyme 2 (ACE2) is an exopeptidase that catalyzes the conversion of angiotensin II to angiotensin 1-7. ACE2 receptor has recently been identified as the entry point of the severe acute respiratory syndrome 2 coronavirus (SARS-CoV-2) in human cells. Objective of the study. To understand the role of ACE 2 receptors in the pathogenesis of new type coronavirus disease – 2019 (COVID-19). Material and Methods. A literature search on the topics of receptor ACE2 was conducted using the MEDLINE database with the PubMed interface. Relevant articles were selected using the following keywords: ACE2, SARS-CoV-2, COVID-19 pathogenesis Results. ACE 2 is widely expressed in human tissues, especially in type II pneumocytes, endothelial cells and enterocytes. SARS-CoV-2 uses the Angiotensin converting enzyme 2 (ACE2) as a binding receptor for protein S (spike), which allows it to infect host cells. For the viral and cell membranes to be able to fuse, protein S must be cleaved by TPRSS2 (transmembrane-serine protease 2), a change that facilitates the entry of viral particles into the cell. During infection, tissues expressing ACE2 become direct targets, resulting in serious pathological changes and progressive dysfunction of several organs or even death. Conclusion. The distribution of ACE2 in different organs is significantly associated with clinical symptoms of SARS-CoV-2 infection. Knowledge of pathogenesis of infection with COVID-19 leads to a proper assessment of the severity and risk of SARS-CoV-2 and to an optimal treatment strategy. |
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Cuvinte-cheie ACE2, SARS-CoV-2, COVID-19 pathogenesis, ECA2, SARS-CoV2, Patogenia COVID-19 |
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