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SM ISO690:2012 UNGUREANU, Cezara, PLAMADEALA, Natalia, DANCUŢA, Mariana. Manifestările clinice, diagnosticul și tratamentul contemporan al leucemiei granulocitare cronice. In: Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”, 21-23 octombrie 2020, Chişinău. Chişinău: USMF, 2020, p. 28. |
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Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” 2020 | ||||||
Congresul "Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”" Chişinău, Moldova, 21-23 octombrie 2020 | ||||||
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Background. Chronic granulocytic leukemia is a chronic myeloproliferative disease characterized by the presence of translocation t(9;22)(q34;q11),also know as the Ph1 and/or BCR-ABL rearrangement.Causal factors remain unknown taday,which fuels enthusiastic studies at the present time. Objective of the study. Study of clinical haemotological manifestations, evaluation of contemporary methods of diagnosis and treatment in pacients with CGL. Material and Methods. Karyotype analysis, blood, bone marrow. Clinical examination, measurement of splenomegaly. The hemogram.Peripheral smear examination.Medullary aspirated examination.Cytogenetic examination-marrow karyotype-FISH. Molecular genetics-rqPCR for the BCR-ABL fusion gene.Osteomedular biopsy. Dtermination of risk scores Sokal, EUTOS. Results. Hematologically, it is characterized by leukocytosis, thrombocytosis and deviation to the left of the leukocyte formula, basophilia. The natural evolution of the disease is bi/triphasic.Criteria of blast phase:>20% blasts in the bone marrow.; The presence of extramedular blastomas;Large groups of blasts on BOM.Accelerated phase criteria;>15 % blasts in peripheral blood.;>30% blasts+promyelocites in peripheral blood.; >20 %basophils in peripheral blood.Trombocytopenia non reliant on the treatment. Clonal cytogenetic evolution. Conclusion. The appearance of tyrosine-kinase inhibitors has brought a new life expectancyfor patients diagnosed with CGL, turning this pathology from incurable malignancy into a manageable and controllable chronic condition.The goals of CGL treatment-achieving haematological, cytogenetic, molecular responses. |
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Cuvinte-cheie chronic granulocytic leukemia, diagnosis staging, treatment, leucemia granulocitară cronică, diagnostic, Tratament |
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