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SM ISO690:2012 CHESOV, Dumitru, MUNTEANU, Oxana, RUSU, Doina, COZLOVSCHI, Victor, SEMIONICĂ, Iurie, BOTNARU, Victor. Rolul specimenelor de aspirat bronșic în diagnosticul tuberculozei pulmonare. In: Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”, 21-23 octombrie 2020, Chişinău. Chişinău: USMF, 2020, p. 279. |
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Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” 2020 | ||||||
Congresul "Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”" Chişinău, Moldova, 21-23 octombrie 2020 | ||||||
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Pag. 279-279 | ||||||
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Background. One-third of pulmonary tuberculosis (PTB) cases in the Republic of Moldova missed the microbiological confirmation. Microbiological assessment of the bronchial aspirate samples could increase the rate of microbiological confirmation of PTB. Objective of the study. To assess the diagnostic value of the standard TB microbiological tests (microscopy, Xpert, culture) in bronchial aspirate (BA) samples for the diagnosis of PTB in patients with negative microscopy and Xpert results in sputum samples. Material and Methods. We retrospectively reviewed microbiological and basic clinical data of all patients who were consulted for suspected PTB at the Institute of Phthtisiopneumology in Moldova during 2017-2018 and had both negative smear and Xpert results in sputum samples and in whom BA by bronchoscopy was obtained under routine conditions. Results. 705 cases with complete microbiological and clinical dataset have been analysed. Of them 39 (5.5%) cases had positive TB culture (23 - only in bronchial aspirate, 9 - in both aspirate and sputum and 7 - only in sputum). Smear microscopy was positive in 1,8% (13 cases) and Xpert in 4,2% (30 cases) of BA samples. The sensitivity and specificity of Xpert in BA were 46,1% (95%CI, 31,6% - 61,4%) and 98,2% (95%CI, 96,9% - 99,0%), correspondingly, and those for microscopy were 20.5% (95%CI, 10.8% 3.5%) and 99.2% (95%CI, 98.5% - 99.7%), correspondingly, using culture as reference method. Conclusion. Assessment of bronchial aspirate samples by routine microbiological tools can increase the rate of microbiological confirmation of PTB. |
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Cuvinte-cheie tuberculosis, bronchial aspirate, sputum, microbiological diagnosis, tuberculoza, aspirat bronșic, spută, diagnostic microbiologic |
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