Articolul precedent |
Articolul urmator |
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Ultima descărcare din IBN: 2022-01-05 21:23 |
SM ISO690:2012 BOTNARU, Victor, MUNTEANU, Oxana. Aspergiloza pulmonară cronică: provocare diagnostică și terapeutică. In: Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”, 21-23 octombrie 2020, Chişinău. Chişinău: USMF, 2020, p. 276. |
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Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” 2020 | ||||||
Congresul "Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”" Chişinău, Moldova, 21-23 octombrie 2020 | ||||||
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Background. Diagnosis of chronic pulmonary aspergillosis (CPA) is a real challenge in clinical practice, particular in case of reduced accessibility for testing fungal infection. The severity of the underlying pulmonary disease, the extent of fungal lung destruction could influence the survival in CPA. Objective of the study. To describe the characteristics of patients with CPA (clinical manifestations, comorbidities, imaging and pathological features, diagnosis, treatment and follow-up) in a tertiary care centre. Material and Methods. A descriptive analysis was performed on 26 patients followed in a tertiary care hospital between I/2015 – XII/2019. Data include CPA subtype, comorbidities, treatment, outcome and follow-up form. The most contributable microbiological evidence was the serum Aspergillus IgG level. Descriptive statistics was performed by SPSS Statistics software version 23. Results. The mean age was 56 years old (28 - 74), with a male predominance (58%). All patients had predisposing pulmonary risk factors: 26 cases - bronchiectasis, 46% - history of tuberculosis, 27% - COPD, 12% - ABPA and severe form of asthma and 1 case (4%) had histiocytosis. Cavitary and fibrosing CPA were the most frequently diagnosed phenotypes (13 cases and 11 cases). Common radiological features were the upper lobes involvement and fungus ball (81%), in 54% of cases being bilateral. Itraconazole was started as a first line treatment in 50% of cases, but only in 5 patients was administered ≥3 months. Nine patients died during the 20 months follow-up period from the diagnosis. Conclusion. Bronchiectasis and pulmonary tuberculosis was found as the most common predisposing risk factor for CPA. Negligence or misdiagnosis of CPA being confused with other diagnoses contribute to diagnostic and therapeutic delay which could explain the high rate mortality. |
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Cuvinte-cheie Chronic pulmonary aspergillosis, bronchiectasis, tuberculosis, aspergiloză pulmonară cronică, Bronşiectazii, tuberculoza |
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