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Ultima descărcare din IBN: 2024-01-29 21:21 |
SM ISO690:2012 SCUTARU, Eugenia, BOTNARU, Victor, RUSU, Doina. Markerii biologici comuni în pneumoniile la imunocompromiși. In: Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”, 21-23 octombrie 2020, Chişinău. Chişinău: USMF, 2020, p. 261. |
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Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” 2020 | ||||||
Congresul "Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”" Chişinău, Moldova, 21-23 octombrie 2020 | ||||||
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Background. The diagnosis of pneumonia in immunocompromised hosts is often difficult, due to the atypical presentation, modest symptoms and imaging. One of the objectives of multiple studies is to highlight the point-to-care biological markers, with a diagnostic and prognostic role. Objective of the study. To analyze the role of usual proinflammatory biological markers in the diagnosis and assessment of the severity of pneumonia in immunocompromised patients. Material and Methods. Common biological markers were analysed: serum leukocyte levels (L) and neutrophil/lymphocyte ratio (NLR), lactate dehydrogenase (LDH), C-reactive protein (CRP) and procalcitonin (PCT). Statistical analysis was performed in the SPSS 22 program, using the association coefficient φ (phi), Mann-Whitney U test. Results. 31 patients with immunosuppression hospitalized in the pneumology department with moderate (35% cases) and severe (65% cases) pneumonia. The etiology of pneumonia was confirmed in 61% of cases. L values ranged from 2000 to 37000/μL (median 8.0). Leukocytosis over 9000/μL as well as leukopenia were recorded in 27% of patients. Serum CRP and LDH were increased in most of cases (61% and 52% respectively), while PCT only in 9% of them. Positive correlation of high CRP level and NLR with disease severity was confirmed (p<0.05) (φ=0.504; p<0.05). Conclusion. Count of serum leukocytes and CRP levels remain the most useful biomarkers for assessing inflammatory syndrome and the severity of pneumonia in immunocompromised patients. The increased level of CRP and NLR correlates positively with the severity of pneumonia in immunocompromised hosts. |
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Cuvinte-cheie pneumonia, immunocompromised, biological markers, pneumonie, imunocompromiși, markeri biologici |
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