Articolul precedent |
Articolul urmator |
420 2 |
Ultima descărcare din IBN: 2023-01-27 11:45 |
SM ISO690:2012 ULINICI, Mariana, VOROJBIT, Valentina. COVID-19 – teste de neutralizare. In: Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”, 21-23 octombrie 2020, Chişinău. Chişinău: USMF, 2020, p. 178. |
EXPORT metadate: Google Scholar Crossref CERIF DataCite Dublin Core |
Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” 2020 | |||||
Congresul "Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”" Chişinău, Moldova, 21-23 octombrie 2020 | |||||
|
|||||
Pag. 178-178 | |||||
|
|||||
Descarcă PDF | |||||
Rezumat | |||||
Background. Recently published seroprevalence studies indicate that in a randomized population the incidence of SARS-CoV-2 is approximately 5%. The road out of the COVID-19 pandemic will depend on the testing for neutralizing antibodies; whether they resulted from virus exposure, or they are vaccine induced. Objective of the study.The aim of this review was to elucidate the availability or the existence of tests that would allow the study of the presence of neutralizing antibodies in patients infected with SARS-CoV-2. Material and Methods. The literature review was performed by accessing the Scopus database (according to the methodological framework suggested by Arksey and O´Malley) and the GoogleScholar search engine. We analyzed 22 articles published before June 1, 2020, in order to study the existence of methods for testing neutralizing antibodies to SARS-CoV-2. Results. The gold standard for neutralizing antibody testing includes the use of the virus, which in the case of SARS-CoV-2 will require BSL-3 biosecurity facilities. A recently published study offers a completely new approach that can be done in BSL-2 laboratories. Two solutions can be considered in this regard: pseudoviruses and surrogate viruses. Pseudoviruses can perform a single cycle of infection because they lose their ability to self-replicate, thus being safer from a biological point of view than infectious viruses. In the case of a SARS-CoV-2 surrogate virus neutralization test, the surrogate would mimic the virus binding receptor. Conclusion. Quantification of neutralizing antibodies will be important to assess postinfectious immunity. |
|||||
Cuvinte-cheie SARS-CoV-2, neutralization tests, COVID-19 immunity, SARS-CoV-2, teste de neutralizare, imunitate COVID-19 |
|||||
|