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SM ISO690:2012 MICȘANSCHI, Pavel, HOLBAN, Tiberiu, COJOCARU, Stela, BÎSTRIŢCHI, Ina, NAGÎŢ, Angela, GHIȚU, Elena. Monitorizarea virusologică a pacienților HIV-infectați, rezistenți la tratamentul antiretroviral de linia I. In: Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”, 21-23 octombrie 2020, Chişinău. Chişinău: USMF, 2020, p. 168. |
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Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” 2020 | ||||||
Congresul "Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”" Chişinău, Moldova, 21-23 octombrie 2020 | ||||||
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Pag. 168-168 | ||||||
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Background. The use of combination antiretroviral therapy has been shown to be effective and useful in controlling HIV infection with prolonging life of infected persons. Major problem in antiretroviral therapy constitutes the development of resistance and the selection of subsequent regimens. Objective of the study. Early detection of patients who did not develop a sustained virological response to the first line ART. Material and Methods. A cohort study was performed on a group of 72 patients with the first-line ART failure during 2011-2018. Patients initiated second line ART and were monitored virologically, immunologically and clinically. The age of the patients included in the study ranged from 23-69 years (mean 38.7 ± 0.3 years). Results. The second line ART was initiated regardless of viral load, in 2/3 of cases a load of> 100,000 copies/ml and increased epidemiological risk were detected.At 5 months after the initiation of the second line - 68 ART they had HIV RNA <25 children / mL, 4 demonstrating a delayed virosological response.The mean CD4 level was 201.61cells/μL: 28 patients had CD4 <350cells, of which 20 - CD4 <200cells, and 8 - CD4 <50cells.Patients with CD4 below 50cells have an increased probability of opportunistic infections and death.The duration from the onset of firstline ART to the onset of virological failure and the onset of the second-line ART was different on average by 4.14 years(1-10 years). Conclusion. The study demonstrates the need to early identification to failure of the first line ART in order to avoid advanced immunosuppression and increased viral load, as well as improving the quality of life of patients and obtaining a sustained virological response to the first line ART. |
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Cuvinte-cheie ART-antiretroviral treatment, HIV-human immunodeficiency virus, TARV-tratament antiretroviral, HIV- virusul imunodeficienței umane |
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