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SM ISO690:2012 BURDUNIUC (POPA), Olga, BÎRCĂ, Ecaterina, BURDUNIUC, Aurelia, GRUMEZA, Maria, BIVOL, Maria. Distribuţia speciilor clinice de candida şi sensibilitatea acestora la antifungice. In: Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”, 21-23 octombrie 2020, Chişinău. Chişinău: USMF, 2020, p. 167. |
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Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” 2020 | ||
Congresul "Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”" Chişinău, Moldova, 21-23 octombrie 2020 | ||
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Background. Opportunistic infections of fungal origin are a challenge of the 21st century. The correct identification of Candida species involved in human mycoses and testing of susceptibility to antifungals are key elements in the management of these infections, especially in the case of antifungal resistance Objective of the study. Analysis of the distribution and antifungal sensitivity patterns of Candida species isolated from various pathological samples during the years 2017-2018. Material and Methods. A descriptive study of Candida species distribution and antifungal susceptibility profile was performed. Identification of isolated Candida species was performed by the MALDI-TOF system, and antifungal susceptibility profiles by Fungitest (Bio-Rad SDP Paris, France). Results. Of the 83 recovered strains, Candida non albicans species predominated - 50.6% and Candida albicans constituted 49.4%. The most common species of the Candida non albicans, were C.parapsilosis (25.3%), C.glabrata (12.0%) and C.krusei (4.8%). Analysis of antifungal susceptibility testing of the recovered strains was found that 95.2% Candida spp. were susceptible to 5-fuorocytosine and 94.0% to ketoconazole and intermediate susceptibility to miconazole 34.9%, itraconazole 15.7%. Candida species were resistant to miconazole in 15.7% of the cases, and in 14.5% of cases each to amphotericin B and fluconazole, 9.6% to itraconazole. Conclusion. C.albicans is the most frequently isolated fungal species, but there is also an increase share of non-albicans Candida species such as C.parapsilosis. |
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Cuvinte-cheie Candida non albicans, Candida albicans, antifungal agents, mycoses, Candida non albicans, Candida albicans, preparate antifungice, micoze |
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