Introduction. The endocrine system coordinates the functions of various organs through hormones that are released into the bloodstream from specific cell types within the endocrine glands. Contemporary endocrine disruptions are multifactorial, many of the conditions are determined by the natural and social environment. In the case of patients with endocrine disorders, the polydimensional approach addresses the diversity of factors, namely from the conceptual positions of different fields: sociology, biostatistics, medical management, social medicine. Still more pronounced, bioethics is involved with a dual role, regulator and direct involvement in the strategy of the medical act  Aim of the study. To explore the multidimensional approach of patients with endocrine disorders. Optimizing the medical act by involving bioethics.  Materials and methods. Consulting of scientific, statistical-sociological and ethno-bioethical publications autochthonous and from abroad. The methods that were applied: analytical, descriptive, bioethical, and sociological.  Results. Endocrine disorders nowadays are a major health challenge and affect more and more people, and the indifference to this situation has an ever more pressing impact on the world's population. In case of endocrine disorders, the doctor-patient relationship must be a special, collaborative one. This is a particular relationship in the context of care of the contemporary patient with endocrine disorder. Nowadays there is a new form of ethical thinking in medicine - the bioethical one - which examines the problems in order to respect the life, autonomy and dignity of each individual throughout his life. Optimization of endocrine medical act through the involvement of bioethics has a favorable role for both the patient population and the general medical field.  Conclusion. 1. The patient with endocrine disorders is a real challenge to approach that requires a psychological, medical treatment throughout his life and a radical change in lifestyle. 2. Endocrine problems are both medical and social, requiring continuous education in multidisciplinary patient teams. 3. A significant importance has the involvement of bioethics in the endocrine medical act.