Introduction. In adults, the adrenal gland consists of two parts: the outer one - the adrenal cortex and one in the inside - the medullary adrenal. The epithelial cortices of the adrenal cortex are arranged in three areas: the glomerular area, which specializes in the production of mineralocorticoids (the main representative being aldosterone), the fasciculating area producing glucocorticoids (cortisol, cortisone) and crosslinked area possessing the ability to deliver sex hormones androgens, estrogens). Aim of the study. Description of physiological and histological changes occurring in the adrenal glands of the fetus. Conclusions. The adrenal glands have an important role in the prenatal period, contributing to the development of the fetus as well as throughout life. From a histological point of view, the adrenal glands at the fetus have a different structure from the adult, which is represented mostly by permanent and temporary fetal cortical and a disorganization of the medullary substance.