Introduction. Reconstruction of defects in the head and neck poses a unique challenge. Unlike other areas of the body, immediate or early closure of head and neck defects is vital for several reasons. Key to success of surgery is choosing an appropriate reconstructive option based on the patient's wishes and necessities. Where possible, free tissue transfer provides the best functional and aesthetic outcomes for the vast majority of defects.  Aim of the study. To present an algorithm to guide choice of flap selection based on our clinic experience and review principles of reconstruction and secondary surgery for head and neck defects.  Materials and methods. Clinical series of patients undergoing head and neck reconstructions in last decade were analyzed and grouped according to the regions: (1) scalp, (2) oral cavity, (3) mandible and (4) neck and choice of reconstruction by different types of free flaps. The study group was consisted from 14 patients, 10 males and 4 females. Average age was 46 years, with age limits 20 - 66 years.  According to etiology, there were 8 defects due to cancer, and 6 defects due to trauma.  Defect sizes varied up to 32 cm. Associated lesions were in 3 cases.   Results. During last decade in the IEM were performed a total of 12 reconstructions. The radial flap was the donor site in 8 reconstructions, followed by the LD flap - 3, free fibula osseocutaneous flap used in 2 cases and omentum - 1 case. In case of reconstruction of the bone and/or soft tissue (mandibular defects) we recommend to use fibula osseocutaneous flap (2), for medium-sized soft tissue defects (7) - non-innervated radial flap; for large defects and necessity to refill the cavity after bone and muscular resection or in the presence of infected granular wounds/osteitis of cranial bones (2) - LD flap using muscles to cover cavities. In case of massive defects (total or subtotal lack of scalp) it can be used the omentum flap. In case of oral mucosa defects and/or tongue with a possible necessity for further innervation (1), we recommend to use radial flap with reinnervation by suturing lateral or medial cutaneous nerve of the forearm to sensory nerves of the recipient site. 85% of the reconstructions were immediately after excisions or trauma. Surgical re-exploration was necessary in 3 patients; the failure rate from marginal necrosis of the flap was in 2%. Other complications encountered in our group: hematoma – 1 case, venous deficiency – 1 case, arterial – 1 case. In 1 case was performed titanium plate fixation for parietal bone defect after excision. All flaps survived and all donor sites were closed primarily. After a mean follow-up time of 8.1 (5-18) months, there were no problem with the donor or recipient sites.  Conclusions. Head and neck defects can lead to devastating cosmetic and functional deficits with resultant psychological, physical, and nutritional detriment. In our experience, free tissue transfers have been shown to be a successful method for one staged reconstruction in all cases, with flap success rates of 98-99% and low re-explorations rate (2 %). In treatment and choice of reconstruction it is important to determine the goals of reconstruction and to select the most appropriate option for the particular defect.