Introduction. Urolithiasis is defined as the presence of stones in the urinary tract. The Global prevalence of the urolithiasis is about 10% of the general population. Its incidence is higher in men aged between 20-55 years. In first 5 years after the stone event, the risk of recurrence ranges between 25 and 50%, that may lead to decreasing of renal function and increasing of morbidity. Aim of the study. The objective of the research was to assess the effectiveness of general metaphylactic measurements in patients with the urinary stone disease. Materials and methods. In this research retrospectively were included 60 patients with urolithiasis that were treated in Department of Urology between 2016 and 2018. The patients with urolithiasis were selected into two study groups. The first group (30 persons) received general metaphylactic treatment; the second group (30 persons) did not implement the metaphylactic recommendations and served as a control group. The general metaphylactic recommendations included: 1) increased hydration up to 2.5-3 L/24h with neutral pH liquids and achieving of diuresis about 2-2.5 L/24h, 2) a diet rich in vegetables and fibers, 3) normal consumption of calcium (Ca) 1-1.2 g/day, 4) decreased consumption of salt - up to 4-5g/day, 5) limited dietary protein intake – up to 0.8-1g/kg/day, 5) change of lifestyle to decrease risk factors (BMI < 25, moderate physical activity etc.). The received data was processed with EpiInfoTM statistical software. The P values <0,05 were considered statistically significant. Results. According to the obtained research data, in the first group the recurrence of urolithiasis happened in 8 (26.7%) patients; in the control group the recurrence rate was 46.7% (14 patients). The metaphylactic measures decreased the rate of recurrence with 20% (absolute risk reduction). The relative risk reduction was 0.429. The Relative Risk of stone recurrence in first group was 0.571, with a 95% Confidence Interval of 0.282-1.158 (p=0,17). Conclusions. According to the research results, the general metaphylactic measures reduce the risk of stone recurrence twice. The results of the treatment of urolithiasis are determined not only by the stone removal but also using general metaphylaxis for certain patients.