Introduction. Chronic rhinosinusitis is an important public health issue, the incidence and prevalence of which has been constantly growing in both the developing and the developed countries, having a negative impact on the quality of life and bringing about significant costs for the diagnosis and treatment. The management of recurrent ting and chronic rhinosinusitis represents a major concern for the otorhinolaryngology service. Traditionally, the treatment of recurrent and chronic rhinosinusitis has been performed by a dministering antibiotics, nasal irrigation with saline solution, decongestant nasal sprays, topical and systemic corticosteroids, antihistamines, antileukotrienes, and surgery as needed. Unfortunately, these methods are not free of risks and adverse effect s. At the same time, the efficiency of standard treatment is lower than expected. Aim of the study. To review the specialized literature and conduct a clinical and immunologic research whose aim is treatment of recurrent and chronic rhinosinusitis in chil dren optimization using cell therapy. Materials and methods. This article summarizes the information from specialized literature about the importance of cell therapy in the treatment of a number of pathologies, particularly its importance in the treatment of rhinosinusal inflammatory pathology. The bibliographic used databases were the following: Cohrane, PubMed, and Medline. Results. A placebo controlled randomized trial of bone marrow derrivated mesenchymal cells (MSC) [Prochymal; Osiris Therapeutics Inc ] in patients with moderate to severe chronic obstructive broncho pneumopathy (COBP) in the United States has proved safe and with no acute infusion related toxicity and no attributed mortality or serious adverse reactions during a two year monitoring peri od. Another randomised controlled study on 24 patients has shown that the administration of marrow derived mononuclear stem cells is feasible and safe in ischemic stroke. Cell therapy combined with physiotherapy has led to improvement of the clinical score s and the functional imaging (fMRI) after 8 weeks, as compared to only physiotherapy, and changes have lasted up to 24 weeks. Stem cells perform a ”Trojan Horse” type of action in the affected nervous tissue, by stimulating the repair mechanisms, which lea ds to behavioural recovery after a stroke. A laboratory research has shown that adipose tissue derived stem cells (ADSCs) may provide a clinical option for the repair of vocal folds mucous Danilov L. (2016) proposed a new method for local immunoc orrection (with autologous mononuclear cells) in the conservative complex treatment of compensated chronic tonsillitis in children, which proved to be very efficient through its positive clinical effect, the normalisation of body ’s pre immune resistance; t he obvious drop down of the high index of allergic reactions , and of the levels of specific cell sensitivity to the antigens of streptococcus, pneumococcus; the increase of the total content of lymphocytes, as well as the level and functional activity of T and B lymphocytes; increase in the efficiency of the cytokine profile and reduction of pro inflammatory cytokines (TNF α, IL 8, IL 1β), as well as and the increase of the serum concentrations of anti inflammatory cytokines (IL 4). Conclusion. The research es presented in this review strongly support the further investigation of the cell therapy methods for the treatment of chronic otorhinolaryngology pathologies.