Introduction. Recently, much attention is paid to the study of obesity and overweight influence on the forecast of chronic kidney disease. The negative impact of overweight on renal function is still poorly understood. Aim of the study. To explore the features of the course of chronic kidney disease in patients with and without concomitant obesity Materials and methods. The study involved 48 patients with stage 2chronic kidney disease (CKD), who were hospitalized in the Nephrology department of Chernivtsi regional clinical hospital. The average age of the patients was 43.5 ± 1.5 years (from 34 to 62 years). CKD was caused by: chronic pyelonephritis in 19 patients (39.5%), chronic glomerulonephritis in 12 patients (25%), diabetic nephropathy in 17 patients (35.5%). CKD duration ranged from 1 to 17 years (on average 8,9 ± 1,5 years). All patients were divided into three groups. Results. An analysis of renal function in the evaluation of patients with the second degree CKD a nd without concomitant obesity as compared with the healthy subjects showed the presence of proteinuria and deterioration of glomerular filtration rate (p <0.05) While studying the blood lipid spectrum indices, we identified impaired lipid serum metabolism as a reliable increase in levels of TC, triglycerides and LDL cholesterol due to lower HDL C in patients with CKD and without obesity compared with healthy individuals (p <0.05 ) Conclusions. The analysis of clinical and laboratory parameters revealed the presence of an imbalance in fat metabolism in obese and non obese patients with chronic kidney disease. However, the changes in patients with II degree obesity were more significant. In this same group the patients showed a more pronounced impairment of r enal function, indicating a more severe course of disease in obese patients. It means that this variant of the disease is more unfavorable.