Introduction. Gout is a comple x disease characterized by hereditary or acquired disorder of purine metabolism and uric acid excretion. It is characterized by hyperuricemia, recurrent arthritis attacks in which the synovial fluid contains monosodium urate crystals and formation of tofy (monosodic urethane monohydrate deposits), especially around the extremities of Aim of the study. Determining the lesion of key organs in gout; correlation analysis of clinical and biochemical indices in patients with gout. Materials and methods. A retrospective study was carried out on patients hospitalized in the rheumatology and arthrology department of the Public Health Care Institution of the Republican Clinical Hospital in the period 2016 2017 diagnosed with gout according to ACR criteria. In the number of 45 patients all were male. The study was performed by laboratory analysis (uric acid in the blood, lipidogram, uric acid in the urine, glycemia) and by instrumental method (radiological Results. It was found that the first sympt oms of gout appeared after the age of 45, in the presence of risk factors like hypertension, obesity, diuretic use. The presence of renal impairment (68% nephrolithiasis), cardiovascular disorder (88% arterial hypertension) and the presence of endocrine pa thology (DZ 75%) was determined in the case of internal pathologies. As a basic treatment it was found that 71% of patients are currently taking allopurinol and 29% of patients are treated with adenuric. Conclusions. Lesion of key organs was determined in gout. After correlation analysis of clinical and biochemical indices in patients I have found correlation between the level of uric acid and triglycerides, the level of uric acid and ABP values, uric acid and degree of obesity, uric acid and glycemia.