Introduction. Epidemiological studies of systemic lupus erythematosus have been reported in the literature in many countries and ethnic groups.Aim of the study. To describe the clinical features, particularly disease activity, damage index and immunological features of 87 systemic lupus erythematosus subjects. Materials and methods. Adult patients (≥18 years) followed in Rheumatology department of PMSI Institute of Cardiology who fulfilled Systemic Lupus International Collaborating Clinics (SLICC) criteria were included. Data was collected by detailed clinical interview, physical examination and laboratory investigations. Hence demographics, SLICC criteria, immuno logical profile, systemic lupus erythematosus disease activity index 2000 (SLEDAI 2K) and SLICC/American College of Rheumatology (ACR) damage index (SDI) were documented. Results. Of the 87 patients, 84 (96.5%) were females and three (3.4%) males. The me an age at lupus onset was 36.7 ± 15.6 years. Mean disease duration was 80.6 ± 112.8 month. The most prevalent clinical SLICC criteria were musculoskeletal, with 74 (94%) of subjects experiencing arthralgia/arthritis, followed by mucocutaneous manifestation s of subacute cutaneous lupus in 65 (74.7%) and alopecia 60 (68.9%) cases. Lupus nephritis (not proven by biopsy) occurred in 32 (36.7%) The most common laboratory SLICC criteria were positive anti dsDNA antibodies in 80 (91.9%) cases, followed b y antinuclear antibodies 66 (75.8%) and low complement (C3, C4 or CH50) levels 50 (57.4%) patients. Mean SLEDAI score was 6.5 ± 4.3 with a range of 2 18 points. Organ damage occurred in 38 (43.6%) patients; mean SDI was 0.7 ± 1.3, with a 0 5 range. Concl usions. The results of the study, general for our country, can be used in the diagnosis and monitoring of SLE, that represents a big challenge for any clinician and justifies the need for this type of study to better characterize the disease, especially in the first years of the disease.