Introduction. In patients with non cystic fibrosis bronchiectasis (NCFB), lung function is highly variable, from a normal spirometry to an airflow obstruction or restriction. Aim of the study. To determine the factors associated with lung function impairment in NCFB patients. Materials and methods. A cross sectional study on 67 patie nts with NCFB admitted to a tertiary level hospital in Republic of Moldova was realized. Clinical, radiological modified Reiff (mReiff) score and lung functional variables were analyzed. The data were presented as mean ± standard deviation in the case of quantitative variables, and as the absolute value and percentage for qualitative variables. To identify variables independently related to FEV1, and their contribution and specific weight in accounting for the total variance of FEV1, a multiple linear reg ression analysis was performed. Results. The cohort consisted of 67 consecutive patients with idiopathic (29 patients, 43%), COPD associated (23 patients, 34%) and post tuberculous (15 cases, 23%) bronchiectasis. Mean age was 58.19 ± 12.05 years, and 66% o f them were mails. More than half of the patients (57%, n=38) were current/previous smokers. A FEV1 more than 80% was registered in 27% (n=18) cases. A mild obstruction, with FEV1 between 50% and 80% was established in 19% (n=13) of patients, a moderate on e with FEV1 ranging from 30% to 50% in 36% of patients, and a severe obstruction with FEV1 less than 30% was characteristic for 18% of cases (n=12). Mean FEV1 was 55.42 ± 28.86%. The majority of the patients (61%, n=41) had a mReiff score with less than 6 points. A worse mReiff score with more than 12 points was determined in 15% (n=10) of cases. When FEV1 was predicted, it was found that mReiff score (Beta = 0.721, p˂0.001), smoking status (Beta = 0.499, p˂0.001), subjects age (Beta = 0.404, p˂0.001) and bronchiectasis etiology (Beta = 0.362, p=0.001) were significant predictors, globally explaining 55% of FEV1 variability (p˂0,001). No significant correlation was recorded between FEV1 and presence of bacterial growth in sputum culture and daily use o f respiratory treatment. Conclusions. The mReiff score, smoking status, subjects age and bronchiectasis etiology are significant determinants of FEV1 in patients with non cystic fibrosis bronchiectasis.