Introduction. Extragenital maternal pathology adversely affects both the intrauterine development of the fetus and the he alth of the newborn. In the case of active tuberculosis, the incidence of tuberculosis poisoning, the degree of hypoxia, the immune system changes, the placental circulation disorders often lead to fetal placental insufficiency, intrauterine hypoxia, and i ntrauterine growth restriction of the fetus. Aim of the study. Analysis of neonatal pathology in 82 children born by mothers with active tuberculosis of respiratory organs. Materials and methods. We analyzed neonatal outcomes in 82 children born to mothe rs with active tuberculosis of respiratory organs during 2000 2010; the control group consisted of 120 children born by healthy mothers. The incidence and character of neonatal complications were recorded.Results. Babies at term predominated 87.8% of c ases, respectively 88.2% of cases (p>0.05). The percentage of premature neonates was 12.2% versus 10.1% in the control group (p>0.05). The mean birth weight was 3135.6 ± 67.2g versus 3216.1 ± 54.3g in the control group (p>0.05). The neonatal morbidity rate in the study group was 49.4% compared to 22.7% in the control group (p<0.001). The intrauterine growth restriction of the fetus was identified in every 4th child born in the study group (24.7% vs. 12.6%, p<0.05). There were 24.7% cases of perinatal EHI (h ypoxic ischemic encephalopathy) compared with 11.8% in the control group(p<0.05). The incidence of intrauterine infections in neonates was 11.1% compared to 0% in the control group(p<0.01). Conclusions. The newborns of patients with active tuberculosis of the respiratory organs showed a high percentage of perinatal pathology, ante and intranatal hypoxia, prematurity, intrauterine growth restriction of the fetus, forming the high risk group for the development of EHI perinatal involvement, with a complicat ed evolution of the early neonatal period.