Introduction. Assisted reproduction technology r epresents a current solution in the treatment of couple sterility. However, the introduction of IVF (in vitro fertilization) into mainstream clinical practice has been accompanied by concerns regarding the number of multiple gestations that it can produce, as multiple births have significant medical consequences for mothers and offspring. Aim of the study. Assessment of the impact of IVF on changes in the rates of multiple births, preterm delivery and low birth weight. Materials and methods. The research was carried out retrospectively in municipal hospital Nr.1 from Chisinau, in obstetrics departments, according to the questionnaire that included specific indicators of birth after IVF. The present study included 106 histories of birth of pre gnant women after IVF, delivery terms 22 41 weeks. Statistical analysis was performed in Microsoft Excel. Results. 84.9% pregnant patients were primiparous with a complicated gynecological and obstetric anamnesis with recurrent miscarriages, extrauterine p regnancies with tubectomies, polycystic ovary syndrome, history of infertility. Primary infertility was recorded in 37(34.9%) patients, secondary infertility in 28(26.4%) patients. According to the type of pregnancy in 60 (56.6%) cases the pregnancy was mo nofetal, in 46(43.4%) cases multiple pregnancy. The multiple pregnancy group (46 cases) was divided in: duplex 43(93.5%) cases, triplex 2(4.3%) cases, quadruplex 1(2.2%) cases. The rate of premature births was 31.1% (33 cases), at term births 63.2% (67 c ases), postterm birth (over 41 weeks) 5.7% (6 cases). Multiple pregnancy is a clear risk factor for preterm birth, however, there is an additional small but statistically significant 23% increase in the relative risk of preterm birth in IVF twins compared with natural twins. In the monofetal births, the range of 500 2499 g included 8(13.4%) newborns, the rate of premature infant being 4 cases. The other newborns had normal weight. The weight of newborns from multiple pregnancies, 96 newborns: 42 (43.7%) had the weight in the range of 2500 3999 g, the other 54(56.3%) weighted in the range of 500 2499 g, with 15 cases of premature births. Conclusions . 1. IVF is a substantial contributor to changes in the very low birth weight rate and delivery before 30 weeks, which is partly related to multiple births. 2. Pregnancies following IVF are at higher risk of perinatal mortality, preterm delivery, small for gestational age, and low or very low birth weight compared with spontaneous conceptions.