Introduction. Chronic pain affects the American population more often than diabetes and cancer altogether. Neurostimulation is the new trend used in the treatment of neurological pathology. Non-invasive cranial neurostimulation includes the following types: transcranial electrical stimulation (tDCS), binaural beats stimulation. ASC is a state in which a person feels a qualitative change in their mental functioning model. tDCS and binaural beats stimulation can induce ASC, in healthy people. Aim of the study. Studying the possibilities of neurostimulation in the induction of ASC, the presence of which would amplify the therapeutic effect in the treatment of chronic pain. Materials and methods. Bibliographic analysis (PubMed).Results. The neurological map of four methods (meditation, hypnosis, trance and daydreaming), that can induce ASC was analyzed. It was established the common component- the prefrontal cortex. The next step was studying pain mapping. We discovered that one of the areas involved in the pain phenomenon is, also, the prefrontal cortex. One of the function of it is that this region processes the pain signals and plans action to reduce the dolor syndrome. tDCS and binaural beats were analyzed as a methods of induction in ASC. The common mechanisms of action, of these two methods are the appearance of theta cortical waves and the involvement of the prefrontal cortex. Conclusions. The prefrontal cortex becomes the main target in the prophylaxis and treatment of chronic pain, through induction in ASC.