Introduction. Infective endocarditis ( is a severe disease. The incidence in patients after dental treatment is 1 to 533.9 treated persons, predominant etiological agents in this case being streptococcus, mainly Streptococcus viridans. Aim of the study. To evaluate the particularities of " endocarditis. Materials and methods. 287 patients with defined IE, mean age 50 0.3 years, were examined clinically and paraclinically. Patients with IE were divided into 2 groups, group I IE caused by oro dental infection IORD ( and group II IORD ( Results. Patients wit h IE with IORD had a history of dental extractions in 31.3%, gingivitis ¬ 26.7%, caries ¬ 17.6%, periodontitis ¬ 1.5%, tonsillitis ¬ 9.9%, and poor oral hygiene in 37.2%. The clinical manifestations that predominated in patients from group I were the tox ico infectious syndrome in 95% and in 28% the musculoskeletal syndrome: myalgia ( arthralgia ( and arthritis 7.6 Positive haemocultures in group I 35.9% vs 30.1% in group II. In group I prevailed Streptococcus viridans in 10.7% and Staphyl ococcus aureus in 8.4%, in group II Staphylococcus in 18.4% and Gram negative bacilli in 4.6%. The echocardiographic examination diagnosed vegetations in 74.8% of cases in group I versus 68.2% in group II. Complications in group I were: pneumonia 35.1%, and nephritis 4.6%. The patients from group I received more often Amoxacillin 17.6% and Gentamicin 50.4%, but those in group II were treated with Cephalosporin 41% and Vancomycin 21.8%. Conclusions. Infective endocarditis of oro dental etiology was more b enign, with a predominant toxico infectious and musculoskeletal syndrome; the main pathogenic agent was Streptococcus viridians, the most frequent complications being pneumonia and nephritis with less aggressive treatment than in those without oro dental pathology.