Introduction. Cardiovascular events increase the mortality rate among women with autoimmune systemic diseases. Chronic inflammation is supposed to be responsible for the accelerated development of atherosclerosis. Endothelial dysfunction(ED) has a primordial role in th e pathogenesis and clinical evolution of cardiovascular disease. Aim of the study. To assess the relationship between endothelial dysfunction and the risk of cardiovascular events in women with autoimmune systemic diseases. Materials and methods. Study g roup included 20 women with autoimmune systemic diseases, established according criteria of diagnosis, divided into 2 subgroups 9 with endothelial dysfunction and 11 without endothelial dysfunction assessed by flow mediated dilatation(FMD) of brachial ar tery using Doppler method. Also we analyzed traditional cardiovascular risk factors hypertension, dyslipidemia, diabetes mellitus, body mass index(BMI), smoking and family history. C reactive protein(CRP), athero plasmatic index(API), ankle brachial inde x(ABI) and the intima media thickness(TIM) of the carotid artery were determined. Results. The patients mean age was 50.7 0.05 years, disease duration 150 0.05(2 504) months. Endothelial dysfunction was found in 9(45.0%) cases from the general group Hypertension was found in 6(67.0%) and 8(73.0%), dyslipidemia 8(87.0%) and 10(90.0%), diabetes mellitus 3(33.0%) and 3(27.0%), smoking 1 ( and 1(9.0%), family history 2 ( and 4(36.0%) in the group with and without endothelial dysfunction, res pectively. BMI deviation was more relevant in the group without endothelial dysfunction 8(72.7%) vs 4 ( in patients with endothelial dysfunction. The level of CRP in women with dysfunctional endothelium was noted in 10(91.0%) cases vs 8(89.0%). Pat hological API was present in 5 ( of women with ED vs 4(36.3%) in subgroup without endothelial dysfunction. Analyzing the values obtained by ABI and TIM, we observed the predominance of abnormal data in the endothelial dysfunction subgroup. Conclusio ns. Endothelial dysfunction detected by flow mediated dilatation using Doppler method suggests the high risk of cardiovascular events in patients with autoimmune systemic diseases.