Background. Polytrauma is a condition defined as the trauma of more than 2 3 anatomic regions, of which 1 with vital risk and it is the leading cause of m ortality and morbidity in modern society, in the most cases being affected young, active people capable of working. As a result, spending on treatment will be extremely high for relatives and health institutions. Etiology of polytrauma, the most frequent i s associated with car accidents, because motor vehicle accidents often occur at a high velocities causing multiple injuries with the loss of work capacity. Case report . A 37 year old woman after a road accident has been hospitalized with multiple trauma. T he first aid was rendered at raional hospital in intensive care department, after 4 days she was transferred at the Clinical Hospital of Orthopaedy and Traumatology. After the investigation (computer tomography, x ray), was established cerebral contusion g r I, subdural hematoma, bone injury: fracture of the right branch of the mandible, comminuted fracture of left distal humeral epimetaphysis AO type C, comminuted fracture of the left distal radial epimetaphysis, fracture of right femoral diaphysis 1/3 medi al distal with displacement of fragments and fracture of right proximal fibula with contusion of right fibular nerve. After neurosurgeon consulting, recommendation was, to operate patients no earlier than two weeks after head trauma. The mandible fracture was fixed by the stomatologist with wire in the 7 th day after trauma. The tactic chosen by surgeon orthoped was pending for stabilization. Because of the subdural hematoma the operation was performed at 14 days after car accident, treatment being performe d for all fractures in one step: open reduction with internal fixation (ORIF) of distal left humerus with plates, closed reduction and fixation with K wires of left distal radial epimetaphysis, ORIF of right femoral diaphysis, right fibular nerve neurolysi s. Conclusions. Decision making in the management of the polytraumatized patient requires the choice of both, time and operative tactics for optimal resolution with low risks in the condition of trauma. In the given case the tactic was successful, stable a nd with favorable prognosis.