Background. Preterm infants are at risk for developing many perinatal complications such as intraventricular haemorrhage (IVH) and subsequent ventriculomegaly. Babies born before 32 weeks of pregnancy present an even higher risk for IVH, an important cause of severe cognitive and motor neurologic impairment in very low birth weight infants. The risk of IVH is inversely related to gestational age and birth weight. Case Report. A male neonate was admitted to the neonatal intensive care unit of Mures County Emergency Hospital. He was delivered by a cesarean section at 30-31 weeks of pregnancy. Birth weight was 1300 grams, the cranial perimeter was 29 cm and Apgar score was 7/8 at 1 and 5 minutes respectively. The primary physical examination revealed mild respiratory distress that evolved in the next two days to bilateral pneumothorax, which was successfully drained. Other abnormalities were found such as hypertrophic cardiomyopathy, atrial septal defect (2 mm) and mild mitral insufficiency. Psychomotor agitation was observed and treated with Midazolam, which caused paralysis of the respiratory center. The newborn was intubated. On the 10th day of life, transfontanellar ultrasound showed intraventricular hemorrhage in resorption and secondary ventriculomegaly. Hypotonia, feeding issues and postprandial vomiting was noted, also high levels of procalcitonin and lactate dehydrogenases were found. On the 16th day of life, bacteriological examination identified an infection with Candida Albicans and Enterococcus Faecium. Treatment with Teicoplanine was initiated. On the 19th day of life, articular pain was observed and the pediatric surgery examination revealed left humeral and forearm fractures, which were successfully treated. On the 25th day of life, the newborn was transferred to the neurosurgical unit for reservoir implant, cerebrospinal fluid (CSF) drainage and further treatment. Due to the favorable evolution, after 20 days he was transferred back to the premature care unit. Conclusions. Recognition of early signs of intraventricular hemorrhage with catastrophic or saltatory pattern, proper prenatal and neonatal care is essential in order to reduce mortality among preterm newborns.