A range of cobalt(III), copper(II) and zinc coordination compounds with oxime ligands were synthesized. For obtained complexes the composition and structure were determined by modern physicochemical methods: elemental analysis, IR and UV-Vis spectroscopies, 1H, 12C, 19F NMR, as well using the single crystal x-ray diffraction. After a conducted screening some complexes were selected which were used as stimulators of biosynthetic processes in some strains of fungi of Aspergillus, Rhizopus, Penicillium, Fusarium genus, for intensification of enzymogenesis (amylases, pectinases, lipases, proteases, cellulase, xylanases, etc..), biomass accumulation, shortening of time of technological process, as well as stabilizers of fungi activity in adverse conditions.