The synthesis of coordination compounds presenting models of natural biological objects and the testing of their action on metabolic processes of microorganisms constitute a promising direction of natural biosynthesis reproduction and control. Since the cobalt dioximates represent models of molecules with vital functions, there was performed the testing of biostimulator properties on some fungal strains. The introduction of cobalt dioximates into the nutrient media of some fungal strains leads to the stimulation of biosynthetic processes (biomass accumulation, enhancement of enzyme activity, reduction of growing period) and stabilizes the enzymeogenesis processes under stress conditions. There were carried out studies regarding the influence of coordination compounds on physiological processes at a number of fungi: Aspergillus niger 33, Aspergillus niger 412, Aspergillus sp., Penicillium viride, Fusarium gibbosum CNMN FD 12, Rhizopus arrhizus, Trichoderma koningii Oudemans CNMN FD 15, etc. For the investigations there were selected mono- and binuclear coordination compounds of different metals (Fe, Co, Cu, Zn) with different degrees of oxidation, containing known dioximes (DH2 - dimethylglyoxime, NioxH2 - 1,2-cyclohexanedionedioxime) as well as new ones (DSamH2 disulfanilamideglyoxime). The ratio of metal: dioxime in complexes can be of 1:1, 1:2 or 1:3. These and other peculiarities give a high degree of diversity of composition, structure and properties among the complexes studied. For example, at the introduction into the medium of the micromycete Rhizopus arrhizus Fischer CNMN FD 03L of the compounds [Co(NioxH)2(An)2]2[ZrF6]·3H2O and [Co(DH)2(An)2]2[TiF6]·2H2O, there was recorded lipolytic activity superior to the control in the variants with 1 mg/L concentration for both complexes (by 22.2% and 33.3% superior to the control). The highest pectolytic activity was recorded in the variants with coordination compounds [Co(DH)2(An)2]2[ZrF6]·2H2O, [Co(DH)2(Nia)2][BF4]·2H2O, at the application of the concentration of 5 mg/L (with 66.6% and 55.5% superior to the control). Along with the increase of greenhouse effect, air temperature and drought frequency, the problem of increasing the drought resistance of the most important agricultural crops has increased in recent years. An important and yet untapped possibility of increasing the productivity of agricultural crops is the use of physiologically active substances with the effect of regulating the growth, development, modification of various metabolic processes, a fact which leads to the enhancement of the adaptive properties of the vegetal organism to suboptimal environmental conditions. The treatment of seeds for sowing and of the foliage apparatus during the vegetation with aqueous solutions containing cobalt coordination compounds enables the optimization of the functional state, growth and development of maize plants, sugar beet, red beet under favorable humidity conditions as well as in a moderate water deficit. The used coordination compounds have the property of activating the vital processes already at the initial stages of individual plant development, stimulate the growth of the root system and shoot, ensure the homeostasis of water status under suboptimal hydride regime, increase the plant productivity, strengthen the protective functions of the organism, increasing the tolerance to the suboptimal factors. Under the conditions of reduced humidity some coordination compounds have an influence of diminishing the effect of drought on the formation of the assimilation apparatus, the accumulation of biomass, and the plant harvest.