Non-steroidal antiinflammatory are drugs commonly used to control pain and inflammation. The aim of our study was to evaluate the efficacy of anti-inflammatory and analgesic effect and tolerability of carprofen-β-cyclodextrin complex compared with carprofen. Studies were performed on 12 dogs of various breeds and ages (8-14 years old) weighing between 8-40 kg which showed different inflammatory osteoarticular roughly similar, diagnosed by clinical examination and, most relevant, the exam imaging. Pain and inflammation were assessed subjectively using analog pain scale (VAS - visual analogue scale). Patients were divided into two groups, each receiving an oral dose of 2 mg/kg every 24 hours of carprofen and carprofen-β-cyclodextrin, for a period of 21 days. Results showed a good analgesic and anti-inflammatory efficacy of the two medicinal products used to treat dogs (carprofen and carprofen-β-cyclodextrin complex), but with a faster therapeutic effect and tolerability much better in the group treated with carprofen-β complex substances cyclodextrin.