Fluconazole and itraconazole are triazole-derived class of known antifungal agents, potentially used against various fungal species. 1,2,4-Triazoles compounds also possess a variety of interesting biological activities such as antibacterial, antitumor, antitubercular, anticonvulsant, anticancer, analgesic, cytotoxic, antiproliferative and plant growth regulatory [1]. Keeping in view biological and medicinal properties of triazole and the potential chemistry of Cu(II) we have synthesized a new azoles according the scheme 1 as a biologically active candidates to obtain complexes with Cu(II). Scheme 1.scheme1) MeCN, reflux 2) NaBH4, i-PrOH 3) NaH, dioxane, refluxThree new Cu(II) coordination compounds with antifungal agent isoconazole (L), namely mononuclear complexes [CuCl2(L)2] (1), and [Cu(O2CMe)2(L)2]·2H2O (2) and coordination polymer [Cu(pht)(L)2]n (where H2pht – o-phthalic acid) were synthesized and characterized by IR spectroscopy, thermogravimetric analysis and X-ray crystallography [2].figureFig.1. Molecular structures of 1 (a) and 2 (b)