Synthesis and preliminary evaluation of several chalcone derivatives as sunscreen compounds
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542.06:547.945:581.5 (1)
Практическая и лабораторная химия, препаративная и экспериментальная химия (138)
Органическая химия (484)
Экология растений. Этология. Растение и окружающая среда (172)
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JUMINA, Jumina, STYANINGRUM, Rizky Woro, SISWANTA, Dwi, TRIONO, Sugeng, PRIASTOMO, Yoga, HARIZAL, Harizal, SHOLIKHAH, Eti Nurwening, ZULKARNAIN, Abdul Karim. Synthesis and preliminary evaluation of several chalcone derivatives as sunscreen compounds. In: Chemistry Journal of Moldova, 2019, nr. 2(14), pp. 90-96. ISSN 1857-1727. DOI: https://doi.org/10.19261/cjm.2019.624
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Chemistry Journal of Moldova
Numărul 2(14) / 2019 / ISSN 1857-1727 /ISSNe 2345-1688

Synthesis and preliminary evaluation of several chalcone derivatives as sunscreen compounds

DOI:https://doi.org/10.19261/cjm.2019.624
CZU: 542.06:547.945:581.5

Pag. 90-96

Jumina Jumina1, Styaningrum Rizky Woro1, Siswanta Dwi1, Triono Sugeng1, Priastomo Yoga1, Harizal Harizal2, Sholikhah Eti Nurwening1, Zulkarnain Abdul Karim1
 
1 Gadjah Mada University,
2 Esa Unggul University, Jakarta
 
 
Disponibil în IBN: 1 ianuarie 2020


Rezumat

Four chalcone derivatives containing chloro and methoxy substituents were synthesized and pre-evaluated as broad-spectrum UV protector with intrinsic antioxidant activity. UV absorbance of chalcones 1-4 showed a wide range of UV absorbance values in UVB and UVA regions ( Λ max= 310-360 nm) and molar absorptivity values ( Λ = 14,000-20,000 M-1cm-1). Chalcones 3 and 4 showed better photostability than chalcones 1 and 2 because the lowering of their absorbance was smaller and slower under UVB irradiation. A combination of the spectra of chalcone derivatives 1-4 indicated that a formulation containing all four will provide a broad-spectrum sunscreen protecting the skin from UVA and UVB.

Cuvinte-cheie
chalcone, photostability, absorbance, sunscreen, broad-spectrum