This work presents the results of extensive research of a-polyglycans based polymers using antibacterial substances of the nitrofuran class, such as furacilin, isofural and others in order to keep an accentuated prolongation effect and to reduce or to avoid the toxicity of these antibacterial substancesfrom utmost to completely [1,2]. The synthesis of conjugated a-polyglycan was performed by using ethyl chloroformate in the presence of triethylamine according the general scheme.formulaFigure. The general scheme of synthesis ofconjugated a-polyglycan.The concentration of antibacterial substances and dextranrangedfrom 10 to 50 mol%. The obtained polymers were purified by reprecipitation from hexane and next diethyl ether. The final structure of compound was confirmed by IR- and UV-VIS spectroscopy. According to IRspectra, there are new absorption bands at 3419.18, 1680.60 and 1573.88cm-1, which confirm the presence of -CO-NH- functional group. Also, the concentration of antibacterial substances in the dextran macromolecules mixtures, confirmed by using IR and UV-VIS spectroscopy, is correlated with the theoretical value. For example, the dextran concentration in the dextran:benzocaine:isofural conjugate is 61% (the polymer conjugate was synthesized in the 50:30:20 mol% ratio). The synthesized polymersare active against S. Aureus, E. Coli and especially Pr. Vulgaris. Polymeric materials with antibacterial properties can be recommended for clinical testing and medical practice.