The delineation and characterization of Groundwater Bodies (GWB) is an important for the development of Integrated Water Management according to EU Water Framework Directive. The aim of this study is an analysis of groundwater quality in the groundwater monitoring network for the characteristic of delineated groundwater bodies. Major ions, dissolved metals and organic micro-pollutants were analyzed for this purpose in 23 samples taken from 8 GWBs. Metals were analyzed by AAS technology and included Fe, Mn, Al, As, Pb, Cd, Cr, Cu, Ni, Zn. Organic micro-pollutants included POPs, BTEX, PAHs, and pesticides. The list of pesticides included: Liufenuron, Trifluralin, Dimetoat, Diazinon, Clorotalonil, Fenitrotion, Malation, Clorpirifos, Triadimefon, Tiametoxam, Cyprodinil, Penconazol, Triadimenol, Procimidon, Endosulfan, Flutriafol, Krezoximmetil, Ciproconazol, Propiconazol, Tebuconazol, Bifentrin, Fenoxycarb, Tetradifon, Fosalon, lambda-Cihalotrin, Permetrin, Piridaben, Cipermetrin, Esfenvalerat, Fluvalinat-tau, Fenvalerat, Difenoconazol, Deltametrin, Azoxstrobin, Dimetomorf. GWB MDDBSGWQ120 is characterized by heterogeneous chemical composition. No samples that meet the requirements of the normative document for this GWB. But in the case of the absence of other water source this GWB can be used for the water supply in the south part of country. This GWB is sensitive to anthropogenic impact. Samples for GWB MDPRTGWQ130 correspond to normative documents besides of nitrate concentration due to the anthropogenic impact. GWBs MDDPBGWD310, MDDPBGWD420 are characterized by the good water quality and all parameters are in admissible interval. GWB MDDPBGWD620 has a high sodium and chloride content. The different types of the groundwater are indicated for all samples of this GWB. GWB MDDPBGWD730 is characterized by slightly alkaline type and high sodium value. GWB MDPRTGWD740 is characterized by slightly alkaline type, high sodium value, and high mineralization. GWB MDPRTGWD820 has a high concentration of sodium, sulphate ion. One sample has a high nitrate concentration. All samples have different types of water. Only three metals have a higher concentration in several samples: Fe, Mn, Al. All this elements have a natural origin. Thus we can conclude that groundwater quality parameters are formed basically under natural factors. Organic micro-pollutants as POPs, pesticides, and BTEX group were indicated on the level below of admissible value or on the detection limits. Only two samples have a relative high value of PAHs substances for GWBs MDDBSGWQ120 MDDPBGWD620. This case can be explained by the artificial pollution from anthropogenic impact. The conclusion is that delineated GWBs are different by the chemical composition. The groundwater quality is changed from north to south part of the Republic of Moldova and depends of climatic and geological conditions.