The wetland area of Low Prut River is a part of Danube Delta and Wetland system. The aim of this study is a characteristic of the environmental status of Beleu Lake, natural reserve of Republic of Moldova. The analysis of POPs, PAHs substances and heavy metals in water and sediment samples was made. The sampling was made at the beginning of June in the period of high water level in Danube and Prut rivers. Water and sediment samples were taken from all lake area including and petrol mining enterprise (Figure). The analysis was made by Gas Chromatography and AAS methods in accredited laboratory. The total PAHs value in water samples was detected from <0.001 to 0.117 micro g/L. The total PAHs value in sediment samples was in the interval from 0.022 – 0.900 mg/kg. The total POPs concentration in water samples is ranged from <0.001 to 0.053 micro g/L. The total POPs concentration in sediment samples is in the interval from 0.030 to 1.448 mg/kg. 20 % of sediment samples have a total POPs value more that 0.10 mg/kg. The chlororganic pesticides and PCBs are principal pollutants. Heavy metals concentration is on the background levels. The conclusion is - natural lake Beleu is under strong anthropogenic impact from different pollution sources including POPs polluted sites from past pesticide storages. The specific sediment monitoring is required for the more correct assessment of the status of this water body.