We conducted a double blinded prospective trial to evaluate the change peripheral excitability effect of millimeter waves (MW) under experimental conditions. Sixty healthy volunteers were exposed to active medical MW generator and to a disabled sham generator. Characteristics of continuous wave electromagnetic output from the active generator were: wavelength 5,6 mm incident power density 10 mW/cm2 and duration of exposure 15 min and 30 min. MW produced a significant (p<0,0001) decreasing of peripheral sensibility in group with duration of exposure 30 min and non-significant decreasing of peripheral sensibility in group with duration of exposure 15 min. decreasing of peripheral sensibility (sensitivity) was appreciated by increasing of cronaxia – one of parameter of peripheral sensibility. With on average 200% of the 30 volunteers 11 (36,6%) reacted to the active MW generator with an decreased peripheral sensitivity by individual reactions varied from 300% to 345% comparison with their own preexposure levels. MW therapy con be used as a supplementary or alternative treatment for decrease peripheral sensitivity for example peripheral pain.