The global population will reach more than 9 billion by 2050, and, by some estimates, agricultural output will have to increase by 50 % to feed all populations. Conventional agriculture focus on maximizing crop yields with the use of synthetic pesticides and fertilizers, which provoke the different ecologic problems. Agriculture is at a critical stage as it tries to balance its nutritional, economic and environmental demands. One of the options for the future is ecological agriculture, which emphasises sustainability, human health, biological conservation and combine scientific knowledge and modern technology with traditional farming practices based on thousands of years of agriculture. The report presents the results of state registration of some baculoviral, bacterial and fungal preparations for combating pest insects, phytopathogen agents and nematodes in ecologic agriculture.