Essential oils of Moldavian Thymus species: Chemical composition, antioxidant, anti-Aspergillus and antigenotoxic activities
Закрыть
Conţinutul numărului revistei
Articolul precedent
Articolul urmator
820 0
SM ISO690:2012
APROTOSOAIE, Ana-Clara, MIRON, Anca, CIOCARLAN, Nina, BREBU, Mihai Adrian, ROŞU, Craita Maria, TRIFAN, Adriana, VOCHIŢA, Gabriela, GHERGHEL, Daniela N., LUCA, Simon Vlad, NIŢĂ, Alexandru, COSTACHE, Irina Iuliana, MIHAI, Cosmin Teodor. Essential oils of Moldavian Thymus species: Chemical composition, antioxidant, anti-Aspergillus and antigenotoxic activities. In: Flavour and Fragrance Journal, 2019, nr. 3(34), pp. 175-186. ISSN 0882-5734. DOI: https://doi.org/10.1002/ffj.3490
EXPORT metadate:
Google Scholar
Crossref
CERIF

DataCite
Dublin Core
Flavour and Fragrance Journal
Numărul 3(34) / 2019 / ISSN 0882-5734

Essential oils of Moldavian Thymus species: Chemical composition, antioxidant, anti-Aspergillus and antigenotoxic activities

DOI: https://doi.org/10.1002/ffj.3490

Pag. 175-186

Aprotosoaie Ana-Clara1, Miron Anca1, Ciocarlan Nina23, Brebu Mihai Adrian4, Roşu Craita Maria5, Trifan Adriana1, Vochiţa Gabriela5, Gherghel Daniela N.5, Luca Simon Vlad1, Niţă Alexandru6, Costache Irina Iuliana1, Mihai Cosmin Teodor1
 
1 University of Medicine and Pharmacy “Grigore T. Popa”, Iasi,
2 National Botanical Garden (Institute) "Alexandru Ciubotaru",
3 Academy of Sciences of Moldova,
4 “Petru Poni” Institute of Macromolecular Chemistry,
5 Institute of Biological Research, Iasi,
6 Alexandru Ioan Cuza University of Iaşi
 
Disponibil în IBN: 19 aprilie 2019


Rezumat

Thymus species are important aromatic, medicinal and culinary plants with a significant economic value. This study evaluated for the first time the chemical composition and in vitro bioactivities of the essential oils (EOs) from five Moldavian Thymus species (T. vulgaris, T. × citriodorus, T. calcareus) and cultivars (T. vulgaris ‘Faustini’, T. citriodorus ‘Aureus’). The main compounds in Thymus EOs were: thymol in T. vulgaris and T. calcareus EOs (55.44% and 55.45%, respectively), lavandulol in T. × citriodorus EO (54.27%), and geraniol in T. citriodorus ‘Aureus’ and T. vulgaris ‘Faustini’ EOs (60.31% and 31.45%, respectively). T. vulgaris and T. calcareus EOs showed the most potent antioxidant activities (EC 50 =0.003 mg/mL in ABTS radical cation scavenging assay) and exhibited significant inhibitory effects against aflatoxin-producing Aspergillus flavus fungus (MIC=0.25 μL/mL). At doses that provided micromolar concentrations of thymol, T. vulgaris and T. calcareus EOs acted genoprotective at preventive and interventional levels against H 2 O 2 -induced genomic damage in V79 cells, the former being more active (6.21% and 5.52% vs. 25.13% and 7.26% tail DNA in pre- and post-treatment protocols, respectively). The genoprotective effects may be ascribed to antioxidant potential and, possibly, to stimulation of DNA repair processes. The Moldavian Thymus species are valuable resources of bioactive EOs for pharmaceutical and food industries (T. vulgaris, T.calcareus) but also for flavor industry and perfumery (T. × citriodorus, T. citriodorus ‘Aureus’, T. vulgaris ‘Faustini’).

Cuvinte-cheie
antigenotoxicity, bioactivity, Chemical composition, essential oils, Thymus species