For decades oxime molecules attract attention as perspective ligands or co-ligands capable of coordinating to metal centers in neutral or anionic forms, giving rise to mono-, multinuclear or polymeric materials. The interest in d10 metals Zn(II) and Cd(II) oxime coordination compounds stems from their diverse applications including photoluminescence, adsorption, biologic activity etc. To elucidate the impact of different oxime ligands on the stereochemistry of the metal center, the reactions between Zn (II)/Cd (II) salts and the mono- and dioxime ligands were carried out either in the absence or in the presence of the biologically relevant nicotinamide-like ligands. Eight mononuclear mixed–ligand compounds [Zn(CH3COO)2(2-pyaoH)2] (1), [Zn(2-pyaoH)2(dmso)2][BF4]2 (2), [Zn(NCS)2(2-pyaoH)2] (3), [M(CH3COO)2(NioxH2)(dmf)(H2O)] (M=Zn(II)/Cd(II)) (4-5), [Zn(CH3COO)2(NioxH2)(S-nia)(H2O)]·dmf (6), [Zn(CH3COO)2(NioxH2)(nia)(H2O)] (7) and [Zn(CH3COO)2(NioxH2)(iso-nia)(H2O)] (8) [2-pyaoH=pyridine-2-aldoxime, NioxH2=1,2-cyclohexanedionedioxime, nia=nicotinamide, iso-nia=isonicotinamide, S-nia=thionicotinamide] were prepared and complexes 1-6 were studied by the single crystal X-ray diffraction method. The structural determination revealed the distorted octahedral coordination geometry around the Zn/Cd centers in each complex. The metal atoms have N4O2 environments in the molecular units 1 and 2, N6 in 3, N2O4 in 4 and 5, and N3O3 in 6. The crystal packing is governed by hydrogen bonding and van der Waals forces. Tested coordination compounds showed a higher stimulatory effect for ordinary amylase biosynthesis. The addition of the complex 1 to the growth medium had a maximal stimulatory effect of 35.63% on 5th day of cultivation for ordinary amylase. The complexes 4-6 in the concentration of 5mg/L have the increased activity of ordinary amylase with 149.98% (4), 157.14% (5) and 142.79% (6) on 5th day of cultivation. On the 6th day of cultivation the productivity of the microorganisms decreased in both experimental and control samples, but the stimulatory effect in the experimental samples is maintained (with 42.32-59.24% over the control of the same day). The results demonstrated that in the optimal concentrations, the complexes 1, 4-6 can be used as stimulators of processes of enzyme genesis (ordinary amylase) from Aspergillus niger CNMN 06 FD micromycete.