Antimicrobial and antifungal activities of iron (III), cobalt (III), nickel (II) and zinc (II) coordination compounds with 2,4-dihydroxyacetophenone 4-allylthiosemicarbazone
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2019-09-29 15:30
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GRAUR, Vasile; TSAPKOV, Viktor; MOLDOVAN, E.; BALAN, Greta; BURDUNIUC, Olga; GULEA, Aurelian; RUDIC, Valeriu. Antimicrobial and antifungal activities of iron (III), cobalt (III), nickel (II) and zinc (II) coordination compounds with 2,4-dihydroxyacetophenone 4-allylthiosemicarbazone. In: Microbial Biotechnology. Ediția 4, 11-12 octombrie 2018, Chișinău. Chișinău, Republica Moldova: Institutul de Microbiologie şi Biotehnologie, 2018, pp. 51-52. ISBN 978-9975-3178-8-7.
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Microbial Biotechnology
Ediția 4, 2018
Conferința "Microbial Biotechnology"
Chișinău, Moldova, 11-12 octombrie 2018

Antimicrobial and antifungal activities of iron (III), cobalt (III), nickel (II) and zinc (II) coordination compounds with 2,4-dihydroxyacetophenone 4-allylthiosemicarbazone


Pag. 51-52

Graur Vasile1, Tsapkov Viktor1, Moldovan E.1, Balan Greta2, Burduniuc Olga3, Gulea Aurelian1, Rudic Valeriu4
 
1 State University of Moldova,
2 ”Nicolae Testemițanu” State University of Medicine and Pharmacy,
3 National Agency for Public Health,
4 Institute of Microbiology and Biotechnology
 
Disponibil în IBN: 18 februarie 2019



Teza

From literature sources it is known that many thiosemicarbazide derivatives and their biometal coordination compounds possess antimicrobial, antituberculous, antifungal, antitumor and other kind of biological properties. Therefore, accumulation and systematization of the experimental data on synthesis and properties of new coordination compounds of biometals with thiosemicarbazide derivatives remains actual nowadays. Iron (III), cobalt (II), nickel (II), and zinc (II) salts react with 2,4-dihydroxyacetophenone 4-allylthiosemicarbazone (H2L) forming coordination compounds with composition: M(HL)2X (M=Fe3+; Co3+; X=Cl-; NO3 -); Ni(HL)X・nH2O (X=Cl-; NO3 -; n=2-3), Zn(H2O)(L). The antimicrobial and antifungal activities of these compounds were studied in vitro using the method of two-fold serial dilutions in liquid nutrient medium (meat infusion broth, pH = 7.0). The substances were dissolved in DMSO in such amounts that the solutions of concentration 10 mg / mL were obtained. The next dilutions were made using meat infusion broth. The antimicrobial activity was tested on standard strains of gram-positive (Staphylococcus aureus ATCC 25923), gram-negative (Escherihia coli ATCC 25922) microorganisms. The antifungal actitivity was studied on Candida albicans. It was determined that H2L thiosemicarbazone manifests antimicrobial activity towards only gram-positive microorganisms and a weak inhibitory activity towards Candida albicans at 500 μg / mL concentration. The nature of the central atom has the main influence on antimicrobial and antifungal activity of the synthesized coordination compounds. The antimicrobial activity of cobalt (III) and iron (III) coordination compounds is lower than of the thiosemicarbazone H2L. Zinc (II) and nickel (II) possess higher activity than the corresponding pro-ligand. Iron (III) coordination compound manifests the highest antifungal activity. All substances except zinc (II) coordination compound manifest neither inhibitory nor bactericidal activity towards gram-negative microorganisms in the studied concentration range.