Two spotted stink bug Perillus bioculatus (Fabricius 1775) is a North American species known as an efficient predator on the Colorado potato beetle (Leptinotarsa decemlineata Say). On the North American continent it is common in Canada, Mexico and the United States of America and has two or three generations per year. In the USA he met almost the entire territory, with the exception of the south-east. In Canada P. bioculatus controls density population of the phytophage in the southern parts of the country. In Mexico the predator P. bioculatus has been registered in many areas (Henry & Froeschner, 1988; Maw et al., 2000). The nymphs are round to oval in shape. There are five instars. The body length of the four instars averages 1-1,5; 2-3; 4-5 and 6-7 mm, respectively. Mature nymphs of the two spotted stink bug are about 8 to 9 mm long. Adults range in length from 8,5 to 11,5 mm. This species has a different color forms – from white and black to red and black (with various intermediate yellow and black forms) with a distinct black “Yshaped” marking on the pronotum and two black spots on the thorax. P. bioculatus overwinters under plant debris around the margins of potato fields in adult stage. This species has been mass-reared for biological control of the Colorado potato beetle. It is known, that an average of 1.5 individuals (nymphs of the later instars or adults) P. bioculatus per plant reduce the number of Colorado potato beetle population to zero in seven days (Ferro, 1994). For this reason, in the second half of the 20th century two spotted stink bug P. bioculatus was introduced into Europe in order to restrain the Colorado potato beetle. However, numerous attempts of the entomologists at acclimatization of the P.bioculatus in Europe were not successful. The first information about registration of the two spotted stink bug on the European continent came in 2004, when he was found in the European part of Turkey (Kivan, 2004). Later it was found in other countries: Russia – in Crimean, Seversk, Slavyansk, Dinsk and Krasnoarmeysk districts of the Krasnodar region, Aksai district of the Rostov region, in the Republic of Adygea (Ismailov & Agasieva, 2010; Ismailov et al., 2014; Artohin et al., 2012), Bulgaria (Simov et al., 2012), Greece (Pericart, 2010), Serbia (Protic & Nebojsa, 2012), Moldova (Derjanschi & Elisoveţcaia, 2013, 2014), as well as in 2015 in the North India, Meerut (Prasad & Rishi, 2015). The populations of the predator in agrocenoses solanaceous crops are affected by different insecticides. Therefore, our attempts to keep the number of natural population entomophage. In 2015-2016 we carried out releases of the entomophage on potato agrocoenosises to maintain the density of the natural population. Purposely to adapt the predator with factor economic impact against the dangerous pest L. decemlineata were carried out the same releases of individuals (adults, nymphs, eggs) P. bioculatus in 2015 on the potato crops in 3 localities: village Pelinei, district Cahul – 50 individuals of P.bioculatus; village Tetcani, dt. Briceni (2 releases) – 1550 individuals; village Brinzeni, dt. Edinet – 130 individuals of P.bioculatus. Total in 2015 were release 1730 individuals (160 adults, 1090 nymphs, 480 eggs). In 2016 we continue releases of the two spotted stink bug P. bioculatus on potato agrocoenosises. Were carried out the same releases of individuals (nymphs and eggs) P. bioculatus on the potato crops in 5 localities: 2 in the Center (Kishinau, about 10 releases, village Ivancea, dt. Orhei) and 3 – in the North of Moldova (v.Tetcani, dt. Briceni, v. Brinzeni, dt. Edineti and v.Unguri, dt. Ocnita). Total in 2016 were release more than 3000 individuals. We have studied the bioecological peculiarities of the predator in a new habitat conditions. Was determined that in the conditions Republic of Moldova during the season develops 3 generations of the P. bioculatus, first in June-July, the second – in July-August and the third in August-September. Were found all the three color forms of the predatory P.bioculatus, which depended on the temperature conditions. Some authors point to the fact that the P.bioculatus prefers eggs and larvae of the Colorado potato beetle, and only adult of predator feed on the imago of L. decemlineata (Lacey et al., 2001). We have been numerous instances of successful hunting older instar nymphs of the P. bioculatus on phytophage adults. We carry out monitoring of the development entomophage (counted the number of egg-laying, nymphs and adults of the predator P.bioculatus) and population density of the pest L. decemlineata on the field of potatoes. We have found that for reducing the density of pest population below the economic threshold sufficient release of older nymphs P. bioculatus in relation predator: phytophage 1:10-1:15. In addition, in agrocoenosis is stored the number other species entomophages: Coccinellidae, Chrysopidae, Aranea, ensuring protection against potato aphids, leafhoppers, etc. The study was performed within the project 15.817.02.12F financed by Academy of Sciences of Moldova.