Copper(ii) thiosemicarbazone complexes induce marked ROS accumulation and promote nrf2-mediated antioxidant response in highly resistant breast cancer cells
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2018-10-11 12:59
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SÎRBU, Angela, PALAMARCIUC, Oleg, BABAK, Maria V., LIM, Jiamin, OHUI, Kateryna A., ENYEDY, Eva Anna, SHOVA, Sergiu, DARVASIOVA, Denisa, RAPTA, Peter, ANG, Wee Han, ARION, Vladimir. Copper(ii) thiosemicarbazone complexes induce marked ROS accumulation and promote nrf2-mediated antioxidant response in highly resistant breast cancer cells. In: Dalton Transactions, 2017, nr. 12(46), pp. 3833-3847. ISSN 1477-9226. DOI: https://doi.org/10.1039/c7dt00283a
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Dalton Transactions
Numărul 12(46) / 2017 / ISSN 1477-9226 /ISSNe 1477-9234

Copper(ii) thiosemicarbazone complexes induce marked ROS accumulation and promote nrf2-mediated antioxidant response in highly resistant breast cancer cells

DOI: https://doi.org/10.1039/c7dt00283a

Pag. 3833-3847

Sîrbu Angela1, Palamarciuc Oleg1, Babak Maria V.2, Lim Jiamin2, Ohui Kateryna A.3, Enyedy Eva Anna4, Shova Sergiu5, Darvasiova Denisa6, Rapta Peter6, Ang Wee Han2, Arion Vladimir3
 
1 Moldova State University,
2 National University of Singapore,
3 University of Vienna,
4 University of Szeged,
5 “Petru Poni” Institute of Macromolecular Chemistry,
6 Slovak University of Technology
 
Disponibil în IBN: 10 iulie 2018


Rezumat

A series of water-soluble sodium salts of 3-formyl-4-hydroxybenzenesulfonic acid thiosemicarbazones (or sodium 5-sulfonate-salicylaldehyde thiosemicarbazones) containing different substituents at the terminal nitrogen atom (H, Me, Et, Ph) and their copper(ii) complexes have been prepared and characterised by elemental analysis, spectroscopic techniques (IR, UV-vis,1H NMR), ESI mass spectrometry, X-ray crystallography and cyclic voltammetry. The proligands and their copper(ii) complexes exhibit moderate water solubility and good stability in aqueous environment, determined by investigating their proton dissociation and complex formation equilibria. The copper(ii) complexes showed moderate anticancer activity in established human cancer cell lines, while the proligands were devoid of cytotoxicity. The anticancer activity of the copper(ii) complexes correlates with their ability to induce ROS accumulation in cells, consistent with their redox potentials within the biological window, triggering the activation of antioxidation defense mechanisms in response to the ROS insult. These studies pave the way for the investigation of ROS-inducing copper(ii) complexes as prospective antiproliferative agents in cancer chemotherapy.

Cuvinte-cheie
Amines, antioxidants, Cell culture, Cells, chemotherapy, copper, crystallography, cyclic voltammetry, diseases, Mass spectrometry, Phenols, Redox reactions, Salts, Spectroscopic analysis